MAKATUSSIN SYROP - AN OVERVIEW

desvenlafaxine will improve the level or result of codeine by influencing hepatic enzyme CYP2D6 metabolism. Use Warning/Monitor. Desvenlafaxine inhibits CYP2D6; with larger desvenlafaxine doses (ie, four hundred mg) minimize the CYP2D6 substrate dose by approximately 50%; no dosage adjustment wanted with desvenlafaxine doses seven consecutive days